The pathophysiology of radiotherapy, chemotherapy, or radiotherapy and chemotherapy-induced oral mucositis is thought to result from a complex process beginning with tissue damage in a five-step model proposed by Sonis. The five stages of RT- and chemotherapy-induced OM occur sequentially, including initiation, signaling, amplification, ulceration, and healing. First, radiation or chemotherapy causes tissue damage leading to death of basal epithelial cells and generation of reactive oxygen species.
• Mucosal erythema
• Patchy ulceration
• Oral Mucositis Assessment Scale
• Oral Rinses
• Prognosis
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